diff --git a/src/core/copyjob.cpp b/src/core/copyjob.cpp
--- a/src/core/copyjob.cpp
+++ b/src/core/copyjob.cpp
@@ -1599,6 +1599,7 @@
     qCDebug(KIO_COPYJOB_DEBUG);
     // Take the first file in the list
     QList<CopyInfo>::Iterator it = files.begin();
+    const auto fileSystem = KFileSystemType::fileSystemType(m_globalDest.toString());
     // Is this URL on the skip list ?
     while (it != files.end() && !bCopyFile) {
         const QString destFile = (*it).uDest.path();
@@ -1606,6 +1607,13 @@
         if (!bCopyFile) {
             it = files.erase(it);
         }
+
+        if (fileSystem == KFileSystemType::Fat && (*it).size > ((1ul << 32) -1)) {  // (1ul << 32 -1) = 4 GB
+            q->setError(ERR_FILE_TOO_LARGE_FOR_FAT32);
+            q->setErrorText(m_globalDest.toDisplayString());
+            q->emitResult();
+            return;
+        }
     }
 
     if (bCopyFile) { // any file to create, finally ?
@@ -1616,7 +1624,6 @@
                 q->emitResult();
                 return;
             }
-            //TODO check if dst mount is msdos and (*it).size exceeds it's limits
         }
 
         const QUrl &uSource = (*it).uSource;
diff --git a/src/core/global.h b/src/core/global.h
--- a/src/core/global.h
+++ b/src/core/global.h
@@ -245,7 +245,8 @@
     ERR_DROP_ON_ITSELF = KJob::UserDefinedError + 70, ///< from KIO::DropJob, @since 5.6
     ERR_CANNOT_MOVE_INTO_ITSELF = KJob::UserDefinedError + 71, ///< emitted by KIO::move, @since 5.18
     ERR_PASSWD_SERVER = KJob::UserDefinedError + 72, ///< returned by SlaveBase::openPasswordDialogV2, @since 5.24
-    ERR_CANNOT_CREATE_SLAVE = KJob::UserDefinedError + 73 ///< used by Slave::createSlave, @since 5.30
+    ERR_CANNOT_CREATE_SLAVE = KJob::UserDefinedError + 73, ///< used by Slave::createSlave, @since 5.30
+    ERR_FILE_TOO_LARGE_FOR_FAT32 = KJob::UserDefinedError + 74 ///< @since 5.52
 };
 
 /**
diff --git a/src/core/job_error.cpp b/src/core/job_error.cpp
--- a/src/core/job_error.cpp
+++ b/src/core/job_error.cpp
@@ -245,8 +245,11 @@
     case KIO::ERR_CANNOT_CREATE_SLAVE:
         result = i18n("Unable to create io-slave. %1", errorText);
         break;
+    case KIO::ERR_FILE_TOO_LARGE_FOR_FAT32:
+        result = xi18n("Cannot transfer <filename>%1</filename> because it is too large. The destination filesystem only supports files up to 4GB", errorText);
+        break;
     default:
-        result = i18n("Unknown error code %1\n%2\nPlease send a full bug report at https://bugs.kde.org.", errorCode, errorText);
+        result = i18n("Unknown error code %1\n%2\nPlease send a full bug report at https://bugs.kde.org.",  errorCode,  errorText);
         break;
     }
 
@@ -1069,6 +1072,13 @@
         solutions << sUpdate << sSysadmin;
         break;
 
+    case KIO::ERR_FILE_TOO_LARGE_FOR_FAT32:
+        errorName = xi18n("Cannot transfer <filename>%1</filename>", errorText);
+        description = xi18n("The file <filename>%1</filename> cannot be transeferred,"
+                            " because the destination filesystem does not support files that large", errorText);
+        solutions << i18n("Reformat the destination drive to use a filesystem that supports files that large.");
+        break;
+
     default:
         // fall back to the plain error...
         errorName = i18n("Undocumented Error");